Originally Posted by fris

Thats one thing I didnt like that was taken out of the UI, I had a client who didnt want the traditional wp-content/uploads for images. he had /pics/filename.jpg etc.

To do this in wordpress 3.5 you can set a define for the constant UPLOADS, its not very well documented, and not used previously because it was set via options.

but add this to your wp-config.php and it will do it for you.