I like to stay at the Hyatt next to the Stupor Dome. It's a short cab ride from the quarter, and there's plenty of restaurants and shopping stuff right there, in case you accidently leave your underwear at Pat O's and need to get some more.
The Royal Sonesta is great, but a little pricy. Right in the middle of the quarter.
Also, DO NOT MESS WITH THE POLICE. They are generally ok folks, but they don't take any crap, period.
Have a blast. It's a great place for it.