Originally Posted by omgitsmike

For a one time payment I would just make a wallet, accept the payment, and then cash out to USD with an exchange like Coinbase.

There are also services out there like Bitpay that accept the BTC and give you the USD equivalent, but they charge a small transaction fee for the convenience. Then you don't really have to mess with having Bitcoin, you just get your cash.

If you want to receive them on a regular basis, you may want to look into what is compatible with your software. Our billing software has an add-on from Coinbase which allows our client's invoices to be paid in Bitcoin. We accept payments in BTC which we receive in BTC. Every once in a while we use Coinbase to "cash out" to USD.

The natural followup question is whether it is worth the hassle. Speaking in broad, sweeping strokes, in my experience people who pay with BTC choose a vendor who accepts BTC and rule out everyone else. So while it hasn't driven wild amounts of business, it has opened us to a completely new niche with little competition and we usually win those sales by default.